LiC32 (P02578) Protein Card

General Information
Name LiC32
Organism Conus lividus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor LiC32 precursor (1675)
Notes this sequence was directly derived from the precursor: some post-translational modifications may be missing.

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family tau conotoxin

Sequence
LWQNTWCCRDHLRCC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1932.24
Monoisotopic Mass 1930.79
Isoelectric Point 10.94
Extinction Coefficient [280nm] 11000.00

Activity

Ki: Somatostatin receptors

TargetOrganismKiCompetitorAgonistRef
sst3H. sapiens3.5 uM125I-[Tyr11]-somatostatinPetrel,C. et al. (2013)

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens40+/-510 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Xie,L., Hu,Y., Zhang,J. and Zhao,X. (2006) Identification and molecular diversity of T-superfamily conotoxins from Conus lividus and Conus litteratus Chem Biol Drug Des 68:97-106
Petrel,C., Hocking,H.G., Reynaud,M., Upert,G., Favreau,P., Biass,D., Paolini-Bertrand,M., Peigneur,S., Tytgat,J., Gilles,N., Hartley,O., Boelens,R., Stocklin,R. and Servent,D. (2013) Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor. Biochem. Pharmacol.

Internal links
Protein Precursor LiC32 precursor (1675)
Nucleic acids
Structure

External links
Ncbi Q3YEH5

Tools