This protein sequence has been predicted from the protein prosequence (Ellison et al. 2006). The final arginine is usually cleaved by an enzyme (CPE). The sequence Reg1e, a protein directly purified from the venom duct, seems to be the real mature peptide corresponding to the precursor sequence (it presents an hydroxyproline, a N-terminal amidation and does not have the arginine).
Rg1A (100 nm) significantly inhibited HVA Ca2+ channel currents in rat DRG neurons to 60.6 ± 4.5% of control (Callaghan et al. 2008).
Inhibition of N-type Ca2+ channel current through the GABAB in a9 KO mouse DRG neurons with an IC50 of 22.4 nM (Callaghan et al., 2010). The specific receptor remains unclear.
Inhibited HVA Ca2+ channel current via GABAB receptors in rat DRG neurons with an IC50 of 14.7 nM. (Halai 2011)
Alsharari et al.,2020 reported that RgIA reverses colitis signs in murine dextran sodium sulfate model.