LtXIVA (P02588) Protein Card

General Information
Name LtXIVA
Alternative name(s) Lt14.1,Lt14a
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor LtXIVA precursor (27)
Notes LtXIVa displayed analgesic activity in a hot plate assay [Sun et al. 2011]. Analgesia was also observed against second-phase pain in formalin-induced inflammatory pain model, and in a paw withdrawal threshold test of mechanical pain [Ren et al. 2015]. Effects downstream of nAChR: inhibits Ca(2+) influx, ERK1/2 phosphorylation and c-fos/NOS expression [Ren et al. 2015]. LtXIVA treatment did induce a morphine-dependent phenotype in mice, and genes associated with drug dependence were not up-regulated [Ren et al. 2015]. LtXIVA treatment reversed morphine withdrawal symptoms in mice [Ren et al. 2015].

Classification
Conopeptide class conotoxin
Gene superfamily L superfamily
Cysteine framework XIV
Pharmacological family alpha conotoxin

Sequence
MCPPLCKPSCTNC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1391.71
Monoisotopic Mass 1390.53
Isoelectric Point 10.17
Extinction Coefficient [280nm] NA

Synthetic variants
LtXIVA [K7A]MCPPLCAPSCTNC(nh2)

References
Peng,C., Tang,S., Pi,C., Liu,J., Wang,F., Wang,L., Zhou,W. and Xu,A. (2006) Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with a unique cysteine pattern Peptides 27:2174-2181
Sun,D., Ren,Z., Zeng,X., You,Y., Pan,W., Zhou,M., Wang,L. and Xu,A. (2011) Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity. Peptides 32:300-305
Ren,Z., Wang,L., Qin,M., You,Y., Pan,W., Zhou,L., Sun,D. and Xu,A. (2015) Pharmacological characterization of conotoxin lt14a as a potent non-addictive analgesic. Toxicon 96:57-67
Zhang, H., Fu, Y., Wang, L., Liang, A., Chen, S. and Xu, A. (2019) Identifying novel conopepetides from the venom ducts of Conus litteratus through integrating transcriptomics and proteomics Journal of proteomics 192:346-357

Internal links
Protein Precursor LtXIVA precursor (27)
Nucleic acids
Structure Solution structure of Lt14a

External links
Ncbi Q2I2R5

Tools