PVIA (P02595) Protein Card

General Information
Name PVIA
Alternative name(s) Lockjaw peptide,P6a
Organism Conus purpurascens
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor PVIA precursor (1563)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
EACYAOGTFCGIKOGLCCSEFCLPGVCFG(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
14O4-Hydroxyproline
30nh2C-term amidation
Sequence evidence protein level
Average Mass 2998.47
Monoisotopic Mass 2996.21
Isoelectric Point 4.50
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50Ref
Nav1.2R. norvegicus2.9uMSafo,P. et al. (2000)
Nav1.4R. norvegicus5.2uMSafo,P. et al. (2000)
Nav1.7H. sapiens1.9uMSafo,P. et al. (2000)
R. norvegicus6.4uMSafo,P. et al. (2000)

References
Terlau,H., Shon,K.J., Grilley,M., Stocker,M., Stuhmer,W. and Olivera,B.M. (1996) Strategy for rapid immobilization of prey by a fish-hunting marine snail Nature 381:148-151
Bulaj,G., DeLaCruz,R., Azimi-Zonooz,A., West,P., Watkins,M., Yoshikami,D. and Olivera,B.M. (2001) Delta-conotoxin structure/function through a cladistic analysis Biochemistry 40:13201-13208
Safo,P., Rosenbaum,T., Shcherbatko,A., Choi,D.Y., Han,E., Toledo-Aral,J.J., Olivera,B.M., Brehm,P. and Mandel,G. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA J. Neurosci. 20:76-80
Shon,K.J., Grilley,M.M., Marsh,M., Yoshikami,D., Hall,A.R., Kurz,B., Gray,W.R., Imperial,J.S., Hillyard,D.R. and Olivera,B.M. (1995) Purification, characterization, synthesis, and cloning of the lockjaw peptide from Conus purpurascens venom Biochemistry 34:4913-4918

Internal links
Protein Precursor PVIA precursor (1563)
Nucleic acids
Structure

External links
Ncbi P58913, 2110216A

Tools