LtIIIA (P02625) Protein Card

General Information
Name LtIIIA
Alternative name(s) Lt3.1,Lt3a
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor LtIIIA precursor (1163)
Notes The article describing LtIIIA discovery (Wang et al. 2009) does not identify the pharmacological family, but it acts as an agonist of sodium channel without delaying the inactivation, which corresponds to the iota pharmacological family.

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family iota conotoxin

Sequence
D(Gla)CC(Gla)OQWCDGACDCCS
Modified residues
positionsymbolname
2GlaGamma carboxylic glutamic acid
5GlaGamma carboxylic glutamic acid
6O4-Hydroxyproline
Sequence evidence protein level
Average Mass 1964.96
Monoisotopic Mass 1963.44
Isoelectric Point 1.86
Extinction Coefficient [280nm] 5500.00

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav TTX-SR. norvegicus(Enhancement and not inhibition)36100nMWang,L. et al. (2009)

References
Wang,L., Liu,J., Pi,C., Zeng,X., Zhou,M., Jiang,X., Chen,S., Ren,Z. and Xu,A. (2009) Identification of a novel M-superfamily conotoxin with the ability to enhance tetrodotoxin sensitive sodium currents. Arch. Toxicol.

Internal links
Protein Precursor LtIIIA precursor (1163)
Nucleic acids
Structure

External links
Ncbi ABC74985

Tools