LeDr192 (P02632) Protein Card

General Information
Name LeDr192
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor LeDr192 precursor (1679)

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family

Sequence
ECCEDGWCCTAAPLT(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1596.77
Monoisotopic Mass 1595.55
Isoelectric Point 2.19
Extinction Coefficient [280nm] 5500.00

Activity

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens5+/-510 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Xie,L., Hu,Y., Zhang,J. and Zhao,X. (2006) Identification and molecular diversity of T-superfamily conotoxins from Conus lividus and Conus litteratus Chem Biol Drug Des 68:97-106

Internal links
Protein Precursor LeDr192 precursor (1679)
Nucleic acids
Structure

External links
Ncbi Q3YEH1

Tools