BnIA (P02635) Protein Card

General Information
Name BnIA
Alternative name(s) Bn1.1
Organism Conus bandanus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Bn1.1 precursor (19)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACSVNNPDIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1614.80
Monoisotopic Mass 1613.58
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α1β1δεM. musculus(electrical stimulation of isolated mouse EDL)193 uM+/-10Nguyen,B. et al. (2014)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α7H. sapiens64+/-71 uM350 uM AChNguyen,B. et al. (2014)

References
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. (2004) The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. 279:17596-17606
Nguyen,B., Le Caer,J.P., Aráoz,R., Thai,R., Lamthanh,H., Benoit,E. and Molgó,J. (2014) Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom. Toxicon 91:155-163

Internal links
Protein Precursor Bn1.1 precursor (19)
Nucleic acids
Structure

External links
Ncbi P0CE73

Tools