Conantokin-L (P02637) Protein Card

General Information
Name Conantokin-L
Alternative name(s) Con-L
Organism Conus lynceus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Conantokin-L precursor (1374)
Notes Conantokin-L is active against the NMDA glutamate receptors.

Classification
Conopeptide class conantokin
Gene superfamily B1 superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)VAKMAA(Gla)LAR(Gla)DAVN(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
11GlaGamma carboxylic glutamic acid
15GlaGamma carboxylic glutamic acid
20nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2207.26
Monoisotopic Mass 2205.93
Isoelectric Point 2.20
Extinction Coefficient [280nm] NA

References
Jimenez,E.C., Donevan,S., Walker,C., Zhou,L.M., Nielsen,J., Cruz,L.J., Armstrong,H., White,H.S. and Olivera,B.M. (2002) Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency Epilepsy Res. 51:73-80

Internal links
Protein Precursor Conantokin-L precursor (1374)
Nucleic acids
Structure

External links
Ncbi P69745

Tools