SVIE (P02710) Protein Card

General Information
Name SVIE
Alternative name(s) S6e,SO6,conotoxin-4
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor SVIE precursor (867)
SVIE precursor (2969)

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
DGCSSGGTFCGIHOGLCCSEFCFLWCITFID
Modified residues
positionsymbolname
14O4-Hydroxyproline
Sequence evidence protein level
Average Mass 3329.76
Monoisotopic Mass 3327.29
Isoelectric Point 4.20
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.4R. norvegicus500nM+/-130Leipold,E. et al. (2005)

References
Lu,B.S., Yu,F., Zhao,D., Huang,P.T. and Huang,C.F. (1999) Conopeptides from Conus striatus and Conus textile by cDNA cloning Peptides 20:1139-1144
Kauferstein,S., Melaun,C. and Mebs,D. (2005) Direct cDNA cloning of novel conopeptide precursors of the O-superfamily Peptides 26:361-367
Bulaj,G., DeLaCruz,R., Azimi-Zonooz,A., West,P., Watkins,M., Yoshikami,D. and Olivera,B.M. (2001) Delta-conotoxin structure/function through a cladistic analysis Biochemistry 40:13201-13208
Leipold,E., Hansel,A., Olivera,B.M., Terlau,H. and Heinemann,S.H. (2005) Molecular interaction of delta-conotoxins with voltage-gated sodium channels FEBS Lett. 579:3881-3884

Internal links
Protein Precursor SVIE precursor (867)
SVIE precursor (2969)
Nucleic acids
Structure

External links
Ncbi Q9XZK5, AAD31911

Tools