ArIB (P02752) Protein Card

General Information
Name ArIB
Alternative name(s) Ar1B
Organism Conus arenatus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
DECCSNPACRVNNPHVCRRR
Sequence evidence nucleic acid level
Average Mass 2325.60
Monoisotopic Mass 2323.99
Isoelectric Point 12.03
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus60.1nM1.2100uM AchWhiteaker et al. (2007)
α6/α3β2β3R. norvegicus6.45nM0.74100uM AchWhiteaker et al. (2007)
α7R. norvegicus1.81nM1200uM AchWhiteaker et al. (2007)

Synthetic variants
ArIB [N6R,A8P]RRRCVHPNNVRCPPRSCCED
ArIB [V11L,V16A]RRRCAHPNNLRCAPNSCCED
ArIB [V11L,V16D]RRRCDHPNNLRCAPNSCCED
ArIB [V11L]RRRCVHPNNLRCAPNSCCED

References
Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M. (2007) Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry 46:6628-6638

Internal links
Nucleic acids
Structure

External links

Tools