ArIB [N6R,A8P] (P02753) Protein Card

General Information
Name ArIB [N6R,A8P]
Organism synthetic construct
Protein Type Synthetic
Parent ArIB

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
DECCSRPPCRVNNPHVCRRR
Average Mass 2393.72
Monoisotopic Mass 2392.06
Isoelectric Point 12.33
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus24.4nM100uM AchWhiteaker et al. (2007)
α7R. norvegicus15.9nM200uM AchWhiteaker et al. (2007)

References
Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M. (2007) Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry 46:6628-6638

Internal links
Nucleic acids
Structure

External links

Tools