ArIB [V11L,V16D] (P02756) Protein Card

General Information
Name ArIB [V11L,V16D]
Organism synthetic construct
Protein Type Synthetic
Parent ArIB
Notes Potent and selective inhibitor of human a7 nAChR (Innocent et al. 2008)

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
DECCSNPACRLNNPHDCRRR
Average Mass 2355.58
Monoisotopic Mass 2353.96
Isoelectric Point 10.94
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus>10uM100uM AchWhiteaker et al. (2007)
α6/α3β2β3R. norvegicus828nM100uM AchWhiteaker et al. (2007)
α7R. norvegicus1.09nM200uM AchWhiteaker et al. (2007)

References
Whiteaker, P., Christensen,S., Yoshikami,D., Dowell,C., Watkins,M., Gulyas,J., Rivier,J., Olivera,B.M. and McIntosh,J.M. (2007) Discovery, Synthesis, and Structure Activity of a Highly Selective alpha7 Nicotinic Acetylcholine Receptor Antagonist Biochemistry 46:6628-6638
Innocent,N., Livingstone,P.D., Hone,A., Kimura,A., Young,T., Whiteaker,P., McIntosh,J.M. and Wonnacott,S. (2008) Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors. J. Pharmacol. Exp. Ther. 327:529-537

Internal links
Nucleic acids
Structure

External links

Tools