conomarphin-Mr1 (P02835) Protein Card

General Information
Name conomarphin-Mr1
Alternative name(s) Mr036,conomarphin,marmophine
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor conomarphin-Mr1 precursor (2783)
conomarphin-Mr1 precursor (6001)
conomarphin-Mr1 precursor (6161)
conomarphin-Mr1 precursor (6162)
conomarphin-Mr1 precursor (6163)
Notes Zhang 2010 discovered two truncated peptide of conomarphin that they called conomarphin-8 and conomarphin-14.

Classification
Conopeptide class conomarphin
Gene superfamily M superfamily
Pharmacological family

Sequence
DWEYHAHPKONSfWT
Modified residues
positionsymbolname
10O4-Hydroxyproline
13fD-phenylalanine
Sequence evidence protein level
Average Mass 1931.06
Monoisotopic Mass 1929.84
Isoelectric Point 6.99
Extinction Coefficient [280nm] 12490.00

Synthetic variants
marmophin [d13>D]DWEYHAHPKONSFWT

References
Han,Y., Huang,F., Jiang,H., Liu,L., Wang,Q., Wang,Y., Shao,X., Chi,C., Du,W. and Wang,C. (2008) Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus. FEBS J. 275:1976-1987
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329
Zhang,L., Shao,X., Chi,C. and Wang,C. (2010) Two short D-Phe-containing cysteine-free conopeptides from Conus marmoreus. Peptides 31:177-179

Internal links
Protein Precursor conomarphin-Mr1 precursor (2783)
conomarphin-Mr1 precursor (6001)
conomarphin-Mr1 precursor (6161)
conomarphin-Mr1 precursor (6162)
conomarphin-Mr1 precursor (6163)
Nucleic acids
Structure PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A D-AMINO ACID CONTAINING CONOPEPTIDE, MARMOPHINE, FROM CONUS MARMOREUS

External links

Tools