MrIB C-term amidated (P02849) Protein Card

General Information
Name MrIB C-term amidated
Organism synthetic construct
Protein Type Synthetic
Parent MrIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework X
Pharmacological family chi conotoxin

Sequence
VGVCCGYKLCHOC(nh2)
Modified residues
positionsymbolname
12O4-Hydroxyproline
14nh2C-term amidation
Average Mass 1392.68
Monoisotopic Mass 1391.56
Isoelectric Point 10.34
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Monoamine transporter

TargetOrganismIC50CompetitorRef
NETH. sapiens(IC50 calculated from reported pIC50.)1.4 uM[3H]nisoxetine 4.3 nMBrust,A. et al. (2009)

References
Sharpe,I.A., Gehrmann,J., Loughnan,M.L., Thomas,L., Adams,D.A., Atkins,A., Palant,E., Craik,D.J., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2001) Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. 4:902-907
Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J. (2009) chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 52:6991-7002

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF MRIB-NH2

External links

Tools