ImI [P6A] (P02852) Protein Card

General Information
Name ImI [P6A]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDARCAWRC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Average Mass 1325.51
Monoisotopic Mass 1324.47
Isoelectric Point 10.99
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α7-5HT3 chimaeraG. gallus280uM+/-1515nM I-BgtxServent,D. et al. (1998)
H. sapiens120uM+/-93.75nM 125 I-BgtxQuiram,P.A. and Sine,S.M. (1998)

References
Kang,T.S., Radic,Z., Talley,T.T., Jois,S.D., Taylor,P. and Kini,R.M. (2007) Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry 46:3338-3355
Quiram,P.A. and Sine,S.M. (1998) Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. J. Biol. Chem. 273:11007-11011

Internal links
Nucleic acids
Structure ALA6 VARIANT OF IMI CONOTOXIN

External links

Tools