TxIA (P02881) Protein Card

General Information
Name TxIA
Alternative name(s) Tx1.1,Tx1a
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor TxIA precursor (2882)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSROOCIANNPDLC(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
7O4-Hydroxyproline
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1689.91
Monoisotopic Mass 1688.65
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus(without Hyp and Nh2)2.0nM+/-0.4AchDutertre,S. et al. (2007)
α7R. norvegicus(without Hyp and Nh2)39nM+/-10nicotineDutertre,S. et al. (2007)

References
Dutertre,S., Ulens,C., B├╝ttner,R., Fish,A., van Elk,R., Kendel,Y., Hopping,G., Alewood,P.F., Schroeder,C., Nicke,A., Smit,A.B., Sixma,T.K. and Lewis,R.J. (2007) AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. EMBO J. 26:3858-3867
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L. (2012) Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon 60:1370-1379

Internal links
Protein Precursor TxIA precursor (2882)
Nucleic acids
Structure ACHBP-TARGETED A-CONOTOXIN CORRELATES DISTINCT BINDING ORIENTATIONS WITH NACHR SUBTYPE SELECTIVITY.

External links

Tools