Tx1.2 (P02883) Protein Card

General Information
Name Tx1.2
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Tx1.2 precursor (2884)
Notes Carstens et al, 2016 reported that Tx1.2 inhibited HVA calcium channel currents in rat DRG neurons by 8%.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ROQCCSHOACNVDHPEIC
Modified residues
positionsymbolname
2O4-Hydroxyproline
8O4-Hydroxyproline
Sequence evidence protein level
Average Mass 2037.24
Monoisotopic Mass 2035.78
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

References
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Tx1.2 precursor (2884)
Nucleic acids
Structure

External links

Tools