Tx1.2 (P02883) Protein Card

General Information
Name Tx1.2
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Tx1.2 precursor (2884)
Notes Inhibits calcium currents in rat DRG neurons by 8%, via GABA-B receptor activation. (Carstens et al, 2016)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence
ROQCCSHOACNVDHPEIC
Modified residues
positionsymbolname
2O4-Hydroxyproline
8O4-Hydroxyproline
Sequence evidence protein level
Average Mass 2037.24
Monoisotopic Mass 2035.78
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

References
Bhatia,S., Kil,Y.J., Ueberheide,B., Chait,B.T., Tayo,L., Cruz,L., Lu,B., Yates,J.R. 3rd. and Bern,M. (2012) Constrained de novo sequencing of conotoxins. J. Proteome Res. 11:4191-4200
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Tx1.2 precursor (2884)
Nucleic acids
Structure

External links

Tools