Pn1.2 (P02917) Protein Card

General Information
Name Pn1.2
Organism Conus pennaceus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Pn1.2 precursor (2918)
Notes Inhibits calcium currents in rat DRG neurons by 22%, via GABA-B receptor activation. 3um fully inhibited currents induced by human α7 and human α9α10 nAChRs. (Carstens et al, 2016)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSHPPCFLNNPDYC
Sequence evidence nucleic acid level
Average Mass 1765.96
Monoisotopic Mass 1764.61
Isoelectric Point 6.60
Extinction Coefficient [280nm] 1490.00

References
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Pn1.2 precursor (2918)
Nucleic acids
Structure

External links

Tools