LtVd (P03322) Protein Card

General Information
Name LtVd
Alternative name(s) Lt5d
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Lt5d precursor (1140)
Notes Block tetrodotoxin sensitive (TTX-S) Na channels (Liu et al 2007).

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family mu conotoxin

Sequence
DCCPAKLLCCNP
Sequence evidence protein level
Average Mass 1275.53
Monoisotopic Mass 1274.49
Isoelectric Point 7.00
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50Ref
Nav TTX-RR. norvegicus>150nMLiu,J. et al. (2007)
Nav TTX-SR. norvegicus156.16nMLiu,J. et al. (2007)

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens0+/-1010 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Liu,J., Wu,Q., Pi,C., Zhao,Y., Zhou,M., Wang,L., Chen,S. and Xu,A. (2007) Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels. Peptides 28:2313-2319

Internal links
Protein Precursor Lt5d precursor (1140)
Nucleic acids
Structure

External links

Tools