CVIF (P03340) Protein Card

General Information
Name CVIF
Alternative name(s) C6f
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCRRTSYDCCTGSCRLGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2665.06
Monoisotopic Mass 2663.12
Isoelectric Point 12.54
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillRef
Cav1.2R. norvegicus>3uMBerecki,G. et al. (2010)
Cav1.3R. norvegicus>3uMBerecki,G. et al. (2010)
Cav2.2R. norvegicus19.9nM+/-3.20.51Berecki,G. et al. (2010)
34.3 nM+/-2.10.42Berecki et al. (2014)
Cav2.3R. norvegicus>3uMBerecki,G. et al. (2010)

Percentage inhibition: Voltage-Gated Calcium Channels

TargetOrganism% inhibitionConcentrationRef
Cav2.1R. norvegicus103uMBerecki,G. et al. (2010)

References
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J. (2010) Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. 77:139-148
Berecki, G., Daly, N.L., Huang, Y.H., Vink, S., Craik, D.J., Alewood, P.F. and Adams, D.J. (2014) Effects of arginine 10 to lysine substitution on ω‐conotoxin CVIE and CVIF block of Cav 2.2 channels British journal of pharmacology 171:3313-3327

Internal links
Nucleic acids
Structure

External links

Tools