CVIF (P03340) Protein Card

General Information
Name CVIF
Alternative name(s) C6f
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCRRTSYDCCTGSCRLGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2665.06
Monoisotopic Mass 2663.12
Isoelectric Point 12.54
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillRef
Cav1.2R. norvegicus>3uMBerecki,G. et al. (2010)
Cav1.3R. norvegicus>3uMBerecki,G. et al. (2010)
Cav2.2R. norvegicus19.9nM+/-3.20.51Berecki,G. et al. (2010)
Cav2.3R. norvegicus>3uMBerecki,G. et al. (2010)

Percentage inhibition: Voltage-Gated Calcium Channels

TargetOrganism% inhibitionConcentrationRef
Cav2.1R. norvegicus103uMBerecki,G. et al. (2010)

References
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J. (2010) Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. 77:139-148

Internal links
Nucleic acids
Structure

External links

Tools