Conantokin-Pr3 (P03535) Protein Card

General Information
Name Conantokin-Pr3
Alternative name(s) Con-Pr3
Organism Conus parius
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GEP(Gla)VAKWA(Gla)GLR(Gla)KAASN(nh2)
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
14GlaGamma carboxylic glutamic acid
20nh2C-term amidation
Sequence evidence protein level
Average Mass 2173.28
Monoisotopic Mass 2172.01
Isoelectric Point 3.61
Extinction Coefficient [280nm] 5500.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus>10uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2BR. norvegicus0.5uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2CR. norvegicus>10uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2DR. norvegicus8uM200uM glutamateTeichert,R.W. et al. (2007)

References
Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M. (2007) Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. 282:36905-36913

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C8E2
Ncbi P0C8E2

Tools