Conantokin-Pr2 (P03536) Protein Card

General Information
Name Conantokin-Pr2
Alternative name(s) Con-Pr2
Organism Conus parius
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
DEP(Gla)YA(Gla)AIR(Gla)YQLKYGKI
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
11GlaGamma carboxylic glutamic acid
Sequence evidence protein level
Average Mass 2447.60
Monoisotopic Mass 2446.12
Isoelectric Point 6.12
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus>10uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2BR. norvegicus0.5uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2CR. norvegicus>10uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2DR. norvegicus1uM200uM glutamateTeichert,R.W. et al. (2007)

References
Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M. (2007) Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. 282:36905-36913

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C8E1
Ncbi P0C8E1

Tools