Conantokin-Pr1 (P03537) Protein Card

General Information
Name Conantokin-Pr1
Alternative name(s) Con-Pr1
Organism Conus parius
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GED(Gla)YA(Gla)GIR(Gla)YQLIHGKI
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
11GlaGamma carboxylic glutamic acid
Sequence evidence protein level
Average Mass 2352.45
Monoisotopic Mass 2351.05
Isoelectric Point 5.41
Extinction Coefficient [280nm] 2980.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus>10uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2BR. norvegicus0.2uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2CR. norvegicus>10uM200uM glutamateTeichert,R.W. et al. (2007)
GluN2DR. norvegicus1uM 200uM glutamateTeichert,R.W. et al. (2007)

References
Teichert,R.W., Jimenez,E.C., Twede,V., Watkins,M., Hollmann,M., Bulaj,G. and Olivera,B.M. (2007) Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J. Biol. Chem. 282:36905-36913

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C8E0
Ncbi P0C8E0

Tools