Conorfamide-Sr2 (P03538) Protein Card

General Information
Name Conorfamide-Sr2
Alternative name(s) CNF-Sr2
Organism Conus spurius
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Notes Espino et al.2018 reported that Conorfamide-Sr2 against human MRGPRX1 and mouse MRGPRC11 at 10 µM are inactive.

Classification
Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Sequence
GPM(Gla)DPL(Gla)IIRI(nh2)
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
8GlaGamma carboxylic glutamic acid
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1469.67
Monoisotopic Mass 1468.72
Isoelectric Point 2.20
Extinction Coefficient [280nm] NA

References
Aguilar,M.B., Luna-Rami­rez,K.S., Echeverria,D., Falcon,A., Olivera,B.M., Heimer de la Cotera,E.P. and Maillo,M. (2008) Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. Peptides 29:186-195
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. (2018) Conopeptides promote itch through human itch receptor hMgprX1 Toxicon 154:28-34

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P85871
Ncbi P85871

Tools