Conorfamide-Sr2 (P03538) Protein Card

General Information
Name Conorfamide-Sr2
Alternative name(s) CNF-Sr2
Organism Conus spurius
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Notes Espino et al.2018 reported that Conorfamide-Sr2 against human MRGPRX1 and mouse MRGPRC11 at 10 µM are inactive.

Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Modified residues
4GlaGamma carboxylic glutamic acid
8GlaGamma carboxylic glutamic acid
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1469.67
Monoisotopic Mass 1468.72
Isoelectric Point 2.20
Extinction Coefficient [280nm] NA

Aguilar,M.B., Luna-Rami­rez,K.S., Echeverria,D., Falcon,A., Olivera,B.M., Heimer de la Cotera,E.P. and Maillo,M. (2008) Conorfamide-Sr2, a gamma-carboxyglutamate-containing FMRFamide-related peptide from the venom of Conus spurius with activity in mice and mollusks. Peptides 29:186-195
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. (2018) Conopeptides promote itch through human itch receptor hMgprX1 Toxicon 154:28-34

Internal links
Nucleic acids

External links
UniProtKB/Swiss-Prot P85871
Ncbi P85871