GID[Del4] (P03577) Protein Card

General Information
Name GID[Del4]
Alternative name(s) [Δ1-4]G1D,[Δ1–4]GID
Organism synthetic construct
Protein Type Synthetic
Parent GID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
CCSNPACRVNNOHVC
Modified residues
positionsymbolname
12O4-Hydroxyproline
Average Mass 1628.83
Monoisotopic Mass 1627.61
Isoelectric Point 11.65
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus4.6nM1.07100uM AchNicke,A. et al. (2003)
α4β2R. norvegicus670nM1.16100uM AchNicke,A. et al. (2003)
α7R. norvegicus5.5nM1.15100uM AchNicke,A. et al. (2003)

References
Nicke,A., Loughnan,M.L., Millard,E.L., Alewood,P.F., Adams,D.J., Daly,N.L., Craik,D.J. and Lewis,R.J. (2003) Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence J. Biol. Chem. 278:3137-3144

Internal links
Nucleic acids
Structure

External links

Tools