KIIIA[C1A,C9A] (P03578) Protein Card

General Information
Name KIIIA[C1A,C9A]
Alternative name(s) K3A[C1A,C9A]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA
Notes Disulfide isomer of KIIIA[C1A,C9A]:[C2-C15,C4-C16]

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
ACNCSSKWARDHSRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1822.04
Monoisotopic Mass 1820.71
Isoelectric Point 11.65
Extinction Coefficient [280nm] 5500.00

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.1R. norvegicus3+/-21 uMKhoo,K.K. et al. (2009)
Nav1.2R. norvegicus93+/-21 uMHan TS et al. (2009)
Nav1.3R. norvegicus7+/-21 uMKhoo,K.K. et al. (2009)
Nav1.4R. norvegicus85+/-21 uMHan TS et al. (2009)
Nav1.5R. norvegicus1+/-21 uMKhoo,K.K. et al. (2009)
Nav1.6R. norvegicus82+/-21 uMKhoo,K.K. et al. (2009)
Nav1.7M. musculus27+/-11 uMKhoo,K.K. et al. (2009)

References
Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G (2009) Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem 4:406-414
Khoo,K.K., Feng,Z.P., Smith,B.J., Zhang,M.M., Yoshikami,D., Olivera,B.M., Bulaj,G. and Norton,R.S. (2009) Structure of the Analgesic mu-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion. Biochemistry 6:1210-1219

Internal links
Nucleic acids
Structure

External links

Tools