KIIIA[Del1,S3/S4Aop,C9A] (P03581) Protein Card

General Information
Name KIIIA[Del1,S3/S4Aop,C9A]
Alternative name(s) C9A],C9A],K3A[Del1,KIIIA[Del1,S3/S4Aop,S3/S4Aop
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA
Notes Synthetic analog of KIIIA, C1 truncated, C9 to Ala substitution, S3 and S4 substituted with single unnatural residue 5-amino-3-oxo-pentanoic acid.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CNC(Aop)KWARDHARCC(nh2)
Modified residues
positionsymbolname
4Aop5-amino-3-oxo-pentanoic acid
15nh2C-term amidation
Average Mass 1661.91
Monoisotopic Mass 1660.66
Isoelectric Point 11.73
Extinction Coefficient [280nm] 5500.00

References
Han TS, Zhang MM, Walewska A, Gruszczynski P, Robertson CR, Cheatham TE 3rd, Yoshikami D, Olivera BM, Bulaj G (2009) Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics. ChemMedChem 4:406-414

Internal links
Nucleic acids
Structure

External links

Tools