Cp20.3 (P03591) Protein Card

General Information
Name Cp20.3
Organism Conus capitaneus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Cp20.3 precursor (3590)
Notes Framework: This framework was assigned to be XII on discovery of VxXIIA , VxXIIB and VxXIIC 2006, which also had been used for conotoxins from the I superfamily (Brown et al. 2005). Loughnan et al. now propose framework designation XX (see reference).

Dimers: Mature D superfamily peptides form hetero-, homo- and pseudohomodimers (identical sequence, different posttranslational modifications). Entries for mature peptides in ConoServer are for monomers.

Classification
Conopeptide class conotoxin
Gene superfamily D superfamily
Cysteine framework XX
Pharmacological family

Sequence
(Gla)VQ(Gla)CQVDTOGSSWGKCCMTRMCGTMCCSRSVC
TCVYHWRRGHGCSCPG
Modified residues
positionsymbolname
1GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
10O4-Hydroxyproline
Sequence evidence nucleic acid level
Average Mass 5502.17
Monoisotopic Mass 5498.05
Isoelectric Point 10.55
Extinction Coefficient [280nm] 12490.00

References
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729

Internal links
Protein Precursor Cp20.3 precursor (3590)
Nucleic acids
Structure

External links

Tools