Ms20.4 (P03603) Protein Card

General Information
Name Ms20.4
Organism Conus mustelinus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Ms20.4 precursor (3602)
Notes Framework: This framework was assigned to be XII on discovery of VxXIIA , VxXIIB and VxXIIC 2006, which also had been used for conotoxins from the I superfamily (Brown et al. 2005). Loughnan et al. now propose framework designation XX (see reference).

Dimers: Mature D superfamily peptides form hetero-, homo- and pseudohomodimers (identical sequence, different posttranslational modifications). Entries for mature peptides in ConoServer are for monomers.

Classification
Conopeptide class conotoxin
Gene superfamily D superfamily
Cysteine framework XX
Pharmacological family

Sequence
DNE(Gla)ECQINOPGSSWGKCCMTRMCGTMCCARSGCTCV
YHWRRGHGCSCPG
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
10O4-Hydroxyproline
Sequence evidence protein level
Average Mass 5540.18
Monoisotopic Mass 5536.04
Isoelectric Point 9.84
Extinction Coefficient [280nm] 12490.00

References
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729

Internal links
Protein Precursor Ms20.4 precursor (3602)
Nucleic acids
Structure

External links

Tools