Mi20.2 (P03609) Protein Card

General Information
Name Mi20.2
Organism Conus miles
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Mi20.2 precursor (3608)
Notes Framework: This framework was assigned to be XII on discovery of VxXIIA , VxXIIB and VxXIIC 2006, which also had been used for conotoxins from the I superfamily (Brown et al. 2005). Loughnan et al. now propose framework designation XX (see reference).

Dimers: Mature D superfamily peptides form hetero-, homo- and pseudohomodimers (identical sequence, different posttranslational modifications). Entries for mature peptides in ConoServer are for monomers.

Classification
Conopeptide class conotoxin
Gene superfamily D superfamily
Cysteine framework XX
Pharmacological family

Sequence
DVQ(Gla)CQVVTOGSKWGRCCLNRVCGPMCCPASHCYCIY
HRGRGHGCSC
Modified residues
positionsymbolname
4GlaGamma carboxylic glutamic acid
10O4-Hydroxyproline
Sequence evidence nucleic acid level
Average Mass 5211.92
Monoisotopic Mass 5208.07
Isoelectric Point 12.08
Extinction Coefficient [280nm] 8480.00

References
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729

Internal links
Protein Precursor Mi20.2 precursor (3608)
Nucleic acids
Structure

External links

Tools