Conantokin-Br (P03641) Protein Card

General Information
Name Conantokin-Br
Alternative name(s) ConBr
Organism Conus sulcatus
Organism region Indo-Pacific
Protein Type Wild type
Protein precursor Conantokin-Br precursor (3686)
Conantokin-Br precursor (4202)
Notes Conus sulcatus brettinghami is a "subspecies" of Conus sulcatus.

Classification
Conopeptide class conantokin
Gene superfamily B1 superfamily
Pharmacological family

Sequence
GD(Gla)(Gla)YSKFI(Gla)RER(Gla)AGRLDLSKFP
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
14GlaGamma carboxylic glutamic acid
Sequence evidence nucleic acid level
Average Mass 3048.18
Monoisotopic Mass 3046.38
Isoelectric Point 4.80
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus680nM200uM glutamateTwede,V.D. et al. (2009)
GluN2BR. norvegicus140nM200uM glutamateTwede,V.D. et al. (2009)
GluN2CR. norvegicus4.9uM 200uM glutamateTwede,V.D. et al. (2009)
GluN2DR. norvegicus310nM200uM glutamateTwede,V.D. et al. (2009)

Synthetic variants
Conantokin-Br/RGD(Gla)(Gla)YSKFI(Gla)LAR(Gla)NIAKGCKVNCYP
conantokin-Br [R5−6]GD(Gla)(Gla)VAKFI(Gla)RER(Gla)AGRLDLSKFP
conantokin-Br [R7−10]GD(Gla)(Gla)YSKMA(Gla)ERE(Gla)EAGRLDLSKFP
conantokin-Br [Y5V]GD(Gla)(Gla)VSKFI(Gla)RER(Gla)AGRLDLSKFP

References
Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M. (2009) Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry 48:4063-4073

Internal links
Protein Precursor Conantokin-Br precursor (3686)
Conantokin-Br precursor (4202)
Nucleic acids
Structure

External links

Tools