conantokin-R [Br7−9] (P03690) Protein Card

General Information
Name conantokin-R [Br7−9]
Alternative name(s) con-R [Br7−9]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-R
Notes Synthetic conantokin-Br/conantokin-R hybrid peptide.

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)VAKFI(Gla)LAR(Gla)NIAKGCKVNCY
P
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
14GlaGamma carboxylic glutamic acid
Average Mass 3085.36
Monoisotopic Mass 3083.38
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Ionotropic glutamate receptors

TargetOrganism% inhibitionConcentrationAgonistRef
GluN2BR. norvegicus3010uM200uM glutamateTwede,V.D. et al. (2009)
GluN2DR. norvegicus1010uM200uM glutamateTwede,V.D. et al. (2009)

References
Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M. (2009) Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry 48:4063-4073

Internal links
Nucleic acids
Structure

External links

Tools