conantokin-Br [R5−6] (P03691) Protein Card

General Information
Name conantokin-Br [R5−6]
Alternative name(s) con-Br [R5−6]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-Br
Notes Synthetic conantokin-Br/conantokin-R hybrid peptide.

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GD(Gla)(Gla)VAKFI(Gla)RER(Gla)AGRLDLSKFP
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
14GlaGamma carboxylic glutamic acid
Average Mass 2968.14
Monoisotopic Mass 2966.39
Isoelectric Point 4.22
Extinction Coefficient [280nm] NA

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2BR. norvegicus5.2uM200uM glutamateTwede,V.D. et al. (2009)
GluN2DR. norvegicus>100uM200uM glutamateTwede,V.D. et al. (2009)

References
Twede,V.D., Teichert,R.W., Walker,C.S., Gruszczynski,P., Kazmierkiewicz,R., Bulaj,G. and Olivera,B.M. (2009) Conantokin-Br from Conus brettinghami and selectivity determinants for the NR2D subunit of the NMDA receptor. Biochemistry 48:4063-4073

Internal links
Nucleic acids
Structure

External links

Tools