SrIA (P03752) Protein Card

General Information
Name SrIA
Alternative name(s) Sr1A
Organism Conus spurius
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Protein precursor SrIA/SrIB precursor (3751)
Notes SrIB has the same sequence as SrIA except for position 12, which is a glutamate in SrIB and a gamma-carboxylic glutamic acid in SrIA. SrIA and SrIB are encoded by the same gene, and their distinct sequence arises from the partial post-translational modification of position 12.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
RTCCSROTCRM(Gla)YP(Gla)LCG(nh2)
Modified residues
positionsymbolname
7O4-Hydroxyproline
12GlaGamma carboxylic glutamic acid
15GlaGamma carboxylic glutamic acid
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2204.46
Monoisotopic Mass 2202.84
Isoelectric Point 10.50
Extinction Coefficient [280nm] 1490.00

Synthetic variants
Sr1.1(nh2)GCLEPYEMRCTORSCCTR

References
López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E. (2007) Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 274:3972-3985

Internal links
Protein Precursor SrIA/SrIB precursor (3751)
Nucleic acids
Structure

External links

Tools