Tx5b (P03757) Protein Card

General Information
Name Tx5b
Alternative name(s) conotoxin 1
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Tx5b precursor (6094)
Notes This sequence was named by ConoServer. There is an ambiguity between the presence of isoleucines or leucines at positions 6 and 14.

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family

Sequence
KPCCSIHDSSCCGI
Sequence evidence protein level
Average Mass 1448.66
Monoisotopic Mass 1447.53
Isoelectric Point 7.98
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Somatostatin receptors

TargetOrganism% inhibitionConcentrationAgonistRef
sst3H. sapiens-5+/-1510 uM125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)

References
Ueberheide,B.M., Fenyƶ,D., Alewood,P.F. and Chait,B.T. (2009) Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915

Internal links
Protein Precursor Tx5b precursor (6094)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P86258
Ncbi P86258

Tools