PIB (P00038) Protein Card

General Information
Name PIB
Alternative name(s) P1b
Organism Conus purpurascens
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ZSOGCCWNPACVKNRC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
3O4-Hydroxyproline
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1760.00
Monoisotopic Mass 1758.68
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus36nM50uM AchLópez-Vera,E. et al. (2007)
α1β1γδM. musculus45nM50uM AchLópez-Vera,E. et al. (2007)
α2β4R. norvegicus>10uM100uM AchLópez-Vera,E. et al. (2007)
α3β2R. norvegicus>10uM100uM AchLópez-Vera,E. et al. (2007)
α3β4R. norvegicus>10uM100uM AchLópez-Vera,E. et al. (2007)
α7R. norvegicus>10uM100uM AchLópez-Vera,E. et al. (2007)
α9α10R. norvegicus>10uM100uM AchLópez-Vera,E. et al. (2007)

References
López-Vera,E., Jacobsen,R.B., Ellison,M., Olivera,B.M. and Teichert,R.W. (2007) A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors Toxicon 49:1193-1199

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P0C351
Ncbi P0C351

Tools