SrIB (P03901) Protein Card

General Information
Name SrIB
Alternative name(s) Sr1B
Organism Conus spurius
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Protein precursor SrIA/SrIB precursor (3751)
Notes Derives from the same precursor as SrIA but lacks one post translational modification at position 12.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
RTCCSROTCRMEYP(Gla)LCG(nh2)
Modified residues
positionsymbolname
7O4-Hydroxyproline
15GlaGamma carboxylic glutamic acid
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2160.45
Monoisotopic Mass 2158.85
Isoelectric Point 10.50
Extinction Coefficient [280nm] 1490.00

Synthetic variants
SrIB [Gla15E]RTCCSROTCRMEYPELCG(nh2)

References
López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E. (2007) Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 274:3972-3985

Internal links
Protein Precursor SrIA/SrIB precursor (3751)
Nucleic acids
Structure

External links

Tools