EIIA (P04069) Protein Card

General Information
Name EIIA
Alternative name(s) E1.3
Organism Conus ermineus (Atlantic fish-hunting cone)
Organism region Eastern Atlantic and Mediterranean,Western Atlantic and Caribbean
Organism diet piscivorous
Protein Type Wild type
Protein precursor EIIA precursor (3910)
EIIA precursor (3911)

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ZTOGCCWNPACVKNRC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
3O4-Hydroxyproline
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1774.03
Monoisotopic Mass 1772.70
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α1β1γδT. marmorata(low affinity second inflexion)105nM+/-25[125I]-Bgtx (0.35nM)Quinton,L. et al. (2013)
0.46nM+/-0.15 [125I]-Bgtx (0.35nM)Quinton,L. et al. (2013)
α3β2H. sapiens>1uM[3H]-epibatidine (0.5nM)Quinton,L. et al. (2013)
α4β2H. sapiens>1uM [3H]-epibatidine (0.5nM)Quinton,L. et al. (2013)
α7-5HT3 chimaeraG. gallus>1uM[125I]-Bgtx (1nM)Quinton,L. et al. (2013)

References
Quinton,L., Servent,D., Girard,E., Molg├│,J., Le Caer,J.P., Malosse,C., Haidar,E.A., Lecoq,A., Gilles,N. and Chamot-Rooke,J. (2013) Identification and functional characterization of a novel ╬▒-conotoxin (EIIA) from Conus ermineus. Anal Bioanal Chem

Internal links
Protein Precursor EIIA precursor (3910)
EIIA precursor (3911)
Nucleic acids
Structure

External links

Tools