Kn1.2 (P04071) Protein Card

General Information
Name Kn1.2
Organism Conus kinoshitai
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Kn1.2 precursor (3913)
Notes Inhibits calcium currents in rat DRG neurons by 13%, via GABA-B receptor activation. (Carstens et al, 2016)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
PGCCNNPACVKHRCG
Sequence evidence nucleic acid level
Average Mass 1554.79
Monoisotopic Mass 1553.61
Isoelectric Point 11.87
Extinction Coefficient [280nm] NA

References
Puillandre,N. and Olivera,B.M. (2010) Evolution of Conus Peptide Genes: Duplication and Positive Selection in the A-Superfamily. J Mol Evol
Carstens,B.B., Berecki,G., Daniel,J.T., Lee,H.S., Jackson,K.A., Tae,H.S., Sadeghi,M., Castro,J., O (2016) Structure-Activity Studies of Cysteine-Rich a-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif. Angew. Chem. Int. Ed. Engl 55:4692-4696

Internal links
Protein Precursor Kn1.2 precursor (3913)
Nucleic acids
Structure

External links

Tools