RIIIJΔ6-8 (P04235) Protein Card

General Information
Name RIIIJΔ6-8
Organism synthetic construct
Protein Type Synthetic
Parent RIIIJ

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family kappa conotoxin

Sequence
LOOCCSLNKKHCOAOACKYKOCCKS
Modified residues
positionsymbolname
2O4-Hydroxyproline
3O4-Hydroxyproline
13O4-Hydroxyproline
15O4-Hydroxyproline
21O4-Hydroxyproline
Average Mass 2794.29
Monoisotopic Mass 2792.20
Isoelectric Point 11.29
Extinction Coefficient [280nm] 1490.00

References
Chen,P., Dendorfer,A., Finol-Urdaneta,R.K., Terlau,H. and Olivera,B.M. (2010) Biochemical characterization of kM-RIIIJ, a KV1.2 channel blocker: Evaluation of cardioprotective effects of kM-conotoxins. J Biol Chem 285:14882-14889

Internal links
Nucleic acids
Structure

External links

Tools