MVIIA[Y13A] (P04239) Protein Card

General Information
Name MVIIA[Y13A]
Organism synthetic construct
Protein Type Synthetic
Parent MVIIA
Notes IC50 of 350 nM on chick brain synaptic plasma membrane (inhibition of GVIA)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGAKCSRLMADCCTGSCRSGKC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Average Mass 2547.02
Monoisotopic Mass 2545.07
Isoelectric Point 12.02
Extinction Coefficient [280nm] NA

References
Kim,J.I., Takahashi,M., Ohtake,A., Wakamiya,A. and Sato,K. (1995) Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers Biochem. Biophys. Res. Commun. 206:449-454

Internal links
Nucleic acids
Structure

External links

Tools