MVIIA[K2A] (P04240) Protein Card

General Information
Name MVIIA[K2A]
Organism synthetic construct
Protein Type Synthetic
Parent MVIIA
Notes IC50 of 1.2 nM on chick brain synaptic plasma membrane (competition with GVIA) (Kim 1995).

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CAGKGAKCSRLMYDCCTGSCRSGKC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Average Mass 2582.02
Monoisotopic Mass 2580.04
Isoelectric Point 11.95
Extinction Coefficient [280nm] 1490.00

References
Kim,J.I., Takahashi,M., Ohtake,A., Wakamiya,A. and Sato,K. (1995) Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers Biochem. Biophys. Res. Commun. 206:449-454
Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J. (2012) N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers 98:161-165

Internal links
Nucleic acids
Structure

External links

Tools