CVIE-2 (P04243) Protein Card

General Information
Name CVIE-2
Alternative name(s) CVIE
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CVIE-2 precursor (1190)
CVIE-2 precursor (1188)
CVIE-2 precursor (1191)
CVIE-2 precursor (1194)
Notes This sequence was published under the name CVIE but another peptide with a different sequence was already published with this name by Bulaj,G. et al. (2001) Delta-conotoxin structure/function through a cladistic analysis Biochemistry 40:13201-13208.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCRRTSYDCCTGSCRSGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2638.98
Monoisotopic Mass 2637.06
Isoelectric Point 12.54
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillRef
Cav1.2R. norvegicus>3uMBerecki,G. et al. (2010)
Cav1.3R. norvegicus>3uMBerecki,G. et al. (2010)
Cav2.2R. norvegicus2.6nM+/-0.50.45Berecki,G. et al. (2010)
Cav2.3R. norvegicus>3uMBerecki,G. et al. (2010)

Percentage inhibition: Voltage-Gated Calcium Channels

TargetOrganism% inhibitionConcentrationRef
Cav2.1R. norvegicus103uMBerecki,G. et al. (2010)

References
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J. (2010) Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. 77:139-148

Internal links
Protein Precursor CVIE-2 precursor (1190)
CVIE-2 precursor (1188)
CVIE-2 precursor (1191)
CVIE-2 precursor (1194)
Nucleic acids
Structure

External links

Tools