CVIE (P04243) Protein Card

General Information
Name CVIE (named by ConoServer)
Alternative name(s) Ca059
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CVIE precursor (1188)
CVIE precursor (1190)
CVIE precursor (1191)
CVIE precursor (1194)
Notes This sequence was published under the name CVIE but another peptide with a different sequence was already published with this name by Bulaj,G. et al. (2001) Delta-conotoxin structure/function through a cladistic analysis Biochemistry 40:13201-13208.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKGKGASCRRTSYDCCTGSCRSGRC(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence protein level
Average Mass 2638.98
Monoisotopic Mass 2637.06
Isoelectric Point 12.54
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50nhillRef
Cav1.2R. norvegicus>3uMBerecki,G. et al. (2010)
Cav1.3R. norvegicus>3uMBerecki,G. et al. (2010)
Cav2.2R. norvegicus2.6nM+/-0.50.45Berecki,G. et al. (2010)
11.1 nM+/-3.50.51Berecki et al. (2014)
Cav2.3R. norvegicus>3uMBerecki,G. et al. (2010)

Percentage inhibition: Voltage-Gated Calcium Channels

TargetOrganism% inhibitionConcentrationRef
Cav2.1R. norvegicus103uMBerecki,G. et al. (2010)

References
Berecki,G., Motin,L., Haythornthwaite,A., Vink,S., Bansal,P., Drinkwater,R., Wang,C.I., Moretta,M., Lewis,R.J., Alewood,P.F. and Adams,D.J. (2010) Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Mol. Pharmacol. 77:139-148
Berecki, G., Daly, N.L., Huang, Y.H., Vink, S., Craik, D.J., Alewood, P.F. and Adams, D.J. (2014) Effects of arginine 10 to lysine substitution on ω‐conotoxin CVIE and CVIF block of Cav 2.2 channels British journal of pharmacology 171:3313-3327
Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research 14:4372-4381

Internal links
Protein Precursor CVIE precursor (1188)
CVIE precursor (1190)
CVIE precursor (1191)
CVIE precursor (1194)
Nucleic acids
Structure

External links

Tools