AuIB[insC_AG] cyclic (P04251) Protein Card

General Information
Name AuIB[insC_AG] cyclic (named by ConoServer)
Alternative name(s) cAuIB-2
Organism synthetic construct
Protein Type Synthetic
Parent AuIB
Notes Part of the peptide folds into a ribbon connectivity. The information on this page concern the globular (bead) isoform, unless otherwise stated.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSYPPCFATNPDCAG
Average Mass 1683.85
Monoisotopic Mass 1682.56
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4R. norvegicus(ribbon)>300nM0 100nM epibatidineArmishaw,C.J. et al. (2011)
24uM100nM epibatidineArmishaw,C.J. et al. (2011)
α4β2R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α7R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)

References
Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K. (2011) Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. 14:65-76

Internal links
Nucleic acids
Structure

External links

Tools