AuIB[insC_A] cyclic (P04252) Protein Card

General Information
Name AuIB[insC_A] cyclic (named by ConoServer)
Alternative name(s) cAuIB-1
Organism synthetic construct
Protein Type Synthetic
Parent AuIB
Notes The peptide mainly adopts a ribbon connectivity.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
GCCSYPPCFATNPDCA
Average Mass 1626.80
Monoisotopic Mass 1625.54
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α4β2R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α7R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)

References
Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K. (2011) Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. 14:65-76

Internal links
Nucleic acids
Structure

External links

Tools