cAuIB-3 (P04253) Protein Card

General Information
Name cAuIB-3
Organism synthetic construct
Protein Type Synthetic
Parent AuIB
Notes Cyclic AuIB with AGG linker. The peptide mainly adopts the ribbon connectivity.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
GCCSYPPCFATNPDCAGG
Average Mass 1740.91
Monoisotopic Mass 1739.58
Isoelectric Point 1.75
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α4β2R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α7R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)

References
Armishaw,C.J., Daly,N.L., Nevin,S.T., Adams,D.J., Craik,D.J. and Alewood,P.F. (2006) Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists J. Biol. Chem. 281:14136-14143

Internal links
Nucleic acids
Structure

External links

Tools