cAuIB-4 (AGGG) (P04254) Protein Card

General Information
Name cAuIB-4 (AGGG)
Organism synthetic construct
Protein Type Synthetic
Parent AuIB
Notes Cyclic AuIB with AGGG linker. The peptide mainly adopts the ribbon connectivity.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
GCCSYPPCFATNPDCAGGG
Average Mass 1797.96
Monoisotopic Mass 1796.60
Isoelectric Point 1.75
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α4β2R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α7R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)

References
Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K. (2011) Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. 14:65-76

Internal links
Nucleic acids
Structure

External links

Tools