AuIB[insC_GAGAAG] cyclic (P04256) Protein Card

General Information
Name AuIB[insC_GAGAAG] cyclic (named by ConoServer)
Alternative name(s) cAuIB-6 (GAGAAG)
Organism synthetic construct
Protein Type Synthetic
Parent AuIB
Notes The peptide folds using a ribbon (principal isoform) or a globular connectivity (minor isoform). The information on this page concern the ribbon isoform, unless otherwise stated.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
GCCSYPPCFATNPDCGAGAAG
Average Mass 1940.12
Monoisotopic Mass 1938.68
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α4β2R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)
α7R. norvegicus>300uM100nM epibatidineArmishaw,C.J. et al. (2011)

References
Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K. (2011) Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. 14:65-76

Internal links
Nucleic acids
Structure

External links

Tools