Ac-AuIB (P04258) Protein Card

General Information
Name Ac-AuIB
Organism synthetic construct
Protein Type Synthetic
Parent AuIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
(Ac)GCCSYPPCFATNPDC(nh2)
Modified residues
positionsymbolname
1AcN-Acetate (on N-terminus)
17nh2C-term amidation
Average Mass 1614.79
Monoisotopic Mass 1613.54
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β4R. norvegicus17uM100 nM epibatidineArmishaw,C.J. et al. (2011)

References
Armishaw,C.J., Jensen,A.A., Balle,L.D., Scott,K.C., Sørensen,L. and Strømgaard,K. (2011) Improving the stability of α-conotoxin AuIB through N-to-C cyclization: the effect of linker length on stability and activity at nicotinic acetylcholine receptors. Antioxid. Redox Signal. 14:65-76

Internal links
Nucleic acids
Structure

External links

Tools