PIIIA [R14A] (P04290) Protein Card

General Information
Name PIIIA [R14A]
Organism synthetic construct
Protein Type Synthetic
Parent PIIIA
Notes PIIIA [R14A] has a less pronounced effect in NaChBac’s inactivation kinetics which is ~300-fold less potent than PIIIA. The side chain of R14 of PIIIA was suggested to block the pore of the channel.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
ZRLCCGFOKSCRSAQCKOHRCC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
8O4-Hydroxyproline
18O4-Hydroxyproline
23nh2C-term amidation
Average Mass 2519.94
Monoisotopic Mass 2518.05
Isoelectric Point NA
Extinction Coefficient [280nm] NA

References
McArthur,J.R., Singh,G., O Mara,M.L., McMaster,D., Ostroumov,V., Tieleman,D.P. and French,R.J (2011) Orientation of {micro}-Conotoxin PIIIA in a Sodium Channel Vestibule, Based on Voltage Dependence of Its Binding. Mol. Pharmacol. 80:219-227
Finol-Urdaneta, R.K., McArthur, J.R., Korkosh, V.S., Huang, S., McMaster, D., Glavica, R., Tikhonov, D.B., Zhorov, B.S. and French, R.J. (2019) Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA Marine drugs 17:510-527

Internal links
Nucleic acids
Structure

External links

Tools